Profiling analysis of post-translational oxidative modification of amyloid-beta in brain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: INOUE Koichi 静岡県立大学, 薬学部, 講師 (30339519)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 質量分析法 / アルツハイマー / 認知症

Outline of Final Research Achievements

The spontaneous accumulation of chemical modifications within a bio-molecule can be regarded as an aging process. Since the post-translational modification of proteins in the brain may affect the folding and turnover regarding neurons, they reduce the activate protein functionality over time and may be linked to the neurodegenerative pathology. Alzheimer’s disease is diagnosed by the progressive decline in cognitive functions, and has substantially increased among people aged 65 years or more, with a progressive decline in memory, thinking, affections, language, and learning capacity from the normal age-related decline in cognitive functions.This study is a first discussion of how research into one hypothesis, the so-called racemization/isomerization of aspartyl residues in amyloid peptides, is enabling researchers to identify ways to develop early and effective treatments for Alzheimer’s disease.

Free Research Field

物理系薬学