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2014 Fiscal Year Final Research Report

Development of novel antibody drugs for inhibition of autoimmune diseases, based on integrin splicing variant functions

Research Project

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Project/Area Number 24590072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

KON Shigeyuki  北海道大学, 薬学研究科(研究院), 准教授 (90344499)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywordsインテグリン / スプライシングバリアント / 細胞接着 / 酵素阻害剤 / 自己免疫疾患
Outline of Final Research Achievements

We reported that SFα9, α9 integrin splicing variant, is a functional modulator of wild-type α9 integrin. We identified a inhibitor, which inhibits α9 integrin function, by exploring SFα9-binding molecules. The inhibitor protects mice from various autoimmune diseases.
We identified α4 integrin splicing variant, α4B. Although cells expressing α4B only have little binding to ligands of wild-type, cells co-expressing wild-type α4 integrin and α4B exhibits inhibition of wild-type α4 integrin-dependent cell adhesion. Thus, α4B is a endogenous inhibitory molecule for wild-type α4 integrin.

Free Research Field

医歯薬学

URL: 

Published: 2016-06-03  

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