2014 Fiscal Year Final Research Report
Fatty acid elongase ELOVL1: function and diseases
| Project/Area Number |
24590073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
SASSA Takayuki 北海道大学, 薬学研究科(研究院), 講師 (20342793)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 極長鎖脂肪酸 / スフィンゴ脂質 / 皮膚バリア |
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| Outline of Final Research Achievements |
To elucidate the function of saturated and monounsaturated very long-chain fatty acids, we made mice lacking Elovl1, the gene responsible for very long-chain-fatty acid production. Elovl1 knockout mice exhibited impaired epidermal permeability barrier and died neonatally. In the epidermis of Elovl1 knockout mice, the level of acylceramides, the lipids important for epidermal permeability barrier, was severely reduced, demonstrating that Elovl1 is one of the enzyme essential for the synthesis of acylceramides.
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| Free Research Field |
脂質生化学
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