Energy regulation by dietary gut microbial metabolites via short-chain fatty acids receptors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tokyo University of Agriculture and Technology (2013-2014); Kyoto University (2012)
• Principal Investigator: IKUO Kimura 東京農工大学, (連合)農学研究科(研究院), 准教授 (80433689)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脂肪酸受容体 / 脂肪組織 / ノックアウトマウス / GPCR / 短鎖脂肪酸 / 腸内細菌

Outline of Final Research Achievements

We report that short-chain fatty acid receptor GPR43 is abundantly expressed in adipose tissues and GPR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean. We further report that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. Recently, we confirmed that GPR43 was expressed in macrophage in adipose tissue inflammation.

Free Research Field

内分泌代謝