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2015 Fiscal Year Final Research Report

Assessment of the influence of overexpressed-cell surface molecular complexes in cancer characteristics

Research Project

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Project/Area Number 24590082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionSaitama Medical University

Principal Investigator

KOTANI NORIHIRO  埼玉医科大学, 医学部, 准教授 (90342782)

Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI ARISA  高知大学, 学振(PD)研究員 (90553157)
Project Period (FY) 2012-04-01 – 2016-03-31
Keywords膜タンパク質 / 分子間相互作用 / 分子会合体
Outline of Final Research Achievements

Many plasma membrane-resident proteins collaborate with other molecules by molecular interactions in a variety of biological events. Herein, we have identified the molecular complexes (heterodimer complexes) expressed specifically in mouse primary lung cancer cells derived from EML4-ALK transgenic mouse as a mouse model of lung cancer. We also focused on the molecular complexes consist of overexpressed-cell surface molecules to assess whether these complexes give rise to cancer progression.
We found the expression of some cell surface molecules was up-regulated, and these overexpressed molecules formed the complexes with several cell surface molecules (alpha and beta integrin etc.). To assess the influence of the complexes, we have developed the cells expressed these candidate overexpressed-cell surface molecular complexes.

Free Research Field

医歯薬学

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Published: 2017-05-10  

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