2015 Fiscal Year Final Research Report
Study on roles of circadian clock gene in allergic immune response
| Project/Area Number |
24590088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 時計遺伝子 / アレルギー / 喘息 / 肥満細胞 |
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| Outline of Final Research Achievements |
Although many studies have indicated that allergic attack and symptoms were most severe in the early morning, the precise mechanisms by which the circadian clock regulates the time of day-dependent phenotypes in allergic reaction are still unknown. We investigated the roles of the circadian clock gene NFIL3 in the allergic immune responses using NFIL3-deficient mice. In NFIL3-deficient mice, enhanced infiltration of inflammatory cells and development of airway hyperresponsiveness were observed in a mouse asthma model. Ablation of NFIL3 expression limited mast cell functions including cytokine production but did not impact on the development of mast cells.
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| Free Research Field |
免疫学・時間生物学
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