2014 Fiscal Year Final Research Report
Physiological and pathophysiological roles of a novel lipid mediator receptor
| Project/Area Number |
24590097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リゾリン脂質 / 脂質生化学 |
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| Outline of Final Research Achievements |
GPR55 is an orphan G protein-coupled receptor and a putative novel type of cannabinoid receptor. Its endogenous ligand is lysophosphatidylinositol (LPI). This study revealed that high levels of GPR55 mRNA were observed in the immune organs such as spleen and lymph nodes. The expression of GPR55 mRNA in the immune cells was examined. High levels of GPR55 mRNA expression were observed in T and B cells. LPI enhanced the IgG secretion from B cell lines and prompted the proliferation via a GPR55 dependent manner. It seems possible that GPR55 plays important physiological and/or pathophysiological roles in the function of the immune system.
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| Free Research Field |
医歯薬学
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