2014 Fiscal Year Final Research Report
The degradation machinery of cellular and viral proteins
| Project/Area Number |
24590103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ウイルス / ヘルペスウイルス / リンパ腫 / プロテアーゼ / シグナル伝達 / 抗腫瘍薬 |
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| Outline of Final Research Achievements |
Kaposi’s sarcoma-associated herpesvirus (KSHV; also known as HHV-8) is a rhadinovirus of the gamma-herpesvirus subfamily and the eighth human herpesvirus to be discovered. KSHV is the causative agent of Kaposi’s sarcoma and acquired immunodeficiency syndrome (AIDS)-related lymphoproliferative disorders, such as plasmablastic variant multicentric Castleman’s disease and primary effusion lymphoma (PEL). In this study, we demonstrated that KSHV-encoded the latency associated nuclear antigen (LANA) is stabilized by de-ubiquitinating enzyme (HSUSP), and enhances the replication and the maintenance of viral DNA. Forthermore, we found that the pyrrolidinium fullerene (C60) and an allyl sulfide have the antitumor activity against PEL cells, suggesting that fullerene and allyl sulfide may represent a novel therapy for the treatment of PEL.
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| Free Research Field |
生物系薬学
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