2014 Fiscal Year Final Research Report
Molecular Mechanisms for cell growth regulation by Mnk-mediated translational control
| Project/Area Number |
24590105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | シグナル伝達 / プロテインキナーゼ / がん細胞 / 翻訳制御 |
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| Outline of Final Research Achievements |
We investigated molecular mechanisms for cell growth regulation by Mnks-mediated translational control. We found that activation of Mnk1 resulted in rapid phosphorylation of eIF4G at Ser1105/1106. We also showed that inhibition of mTORC1 upregulated phosphorylation of eIF4E at Ser209 in human medulloblastoma cells, and that this feedback phosphorylation of eIF4E was mediated by Mnk2 but not by Mnk1. Furthermore, suppression of Mnk2 activity sensitized medulloblastoma cells to mTOR inhibitors, raising the potential for combination treatments of mTOR and Mnk inhibitors for the treatment of medulloblastoma.
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| Free Research Field |
分子細胞生物学
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