A mechanism of action of a plant ingredient betulin on restoring the suppression of antitumor activity of immune cells by TGF-beta or PGE2.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Toyama Prefectural Institute. for Pharmaceutical Research.
• Principal Investigator: OGASAWARA MASARU 富山県薬事研究所, その他部局等, 研究員 (30443427)
• Co-Investigator(Renkei-kenkyūsha): NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 准教授 (30431761) ; MIYAMOTO Tomomi 富山県薬事研究所, 主任研究員 (20443426) ; YAMASAKI Shimno 富山県薬事研究所, 研究員 (50602182)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ベツリン / 腫瘍

Outline of Final Research Achievements

TGF-βand PGE2 secreted by tumor cells strongly inhibit anti-tumor activity of immune cells, which greatly attenuates the effects of tumor therapy, especially cancer immunotherapy. In this study, we focused on the restoring effects of a plant ingredient betulin on the immunosuppression by TGF-βor PGE2, and conducted an analysis of its mechanism of action. It is suggested that betulin restores the suppressive activity of TGF-βor PGE2 through greatly promoting the effects of immune stimulators.

Free Research Field

免疫薬理学