2015 Fiscal Year Final Research Report
Elucidation of neuroprotective mechanism by endogenous substances with low molecular weight
| Project/Area Number |
24590111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Kume Toshiaki 京都大学, 薬学研究科(研究院), 准教授 (10303843)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 薬理学 / 低分子量生体内機能分子 / セロフェンド酸 / 神経保護 |
|---|
| Outline of Final Research Achievements |
Intravenous administration of serofendic acid protected cardiac myocytes against myocardial ischemia-reperfusion injury in vivo by preserving the functional integrity of mitochondria. Aβ-mediated toxicity is caused by the turn that favors toxic oligomers, which increase generation of ROS. DDC protected cortical neurons against Aβ-induced toxicity by the inhibition of aggregation of Aβ.
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| Free Research Field |
薬理学
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