S1P receptors on neuronal cells as a target of medicine for epilepsy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590112
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kobe University
• Principal Investigator: OKADA Taro 神戸大学, 医学(系)研究科(研究院), 准教授 (80304088)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: スフィンゴシン１－リン酸 / スフィンゴ脂質

Outline of Final Research Achievements

Since it has recently been reported that alpha-synuclein (ASN) in cerebrospinal fluid is a biomarker of epilepsy, we investigated the effect of extracellular ASN on the neuronal cell functions. We found the extracellular ASN causes the inhibition of S1P1 receptor-Gi protein coupling. The ASN effect was subtype specific because it inhibits S1P1 as well as S1P3 receptors but doesn't inhibit S1P2-induced cell signaling. This finding is very important because it was already reported by our group that S1P receptor is involved in the neuronal functions. And this study also suggests the possibility of novel therapeutic strategy for treating epilepsy.

Free Research Field

細胞生物学