Pharmacological research on antidepressant-like effects of GLP-2 on refractory depression.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590126
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tokyo University of Science
• Principal Investigator: OKA Jun-Ichiro 東京理科大学, 薬学部, 教授 (40134613)
• Co-Investigator(Renkei-kenkyūsha): HAMADA Sachie (SASAKI Sachie) 東京理科大学, 薬学部, ポストドクトラル研究員 (00399320)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: うつ病 / 高血圧 / GLP-2 / ストレス / 経鼻投与

Outline of Final Research Achievements

Abnormalities in the hypothalamic-pituitary-adrenal (HPA)-axis have been thought to induce refractory depression. Glucagon-like peptide-2 (GLP-2) exhibited antidepressant-like effects in ACTH-treated imipramine-resistant depression model mice through an inhibition on the release of CRH from the PVN in the hypothalamus and the restoration of neurogenesis in the SGZ of the hippocampal dentate gyrus. Intranasal administration of the newly synthesized GLP-2 derivative also showed antidepressant-like effects in ACTH-treated mice, indicating a possible clinical treatment for major depression. Furthermore, we showed memory improving effects and anxiolytic effects of GLP-2 in mice, as well as the hypotensive effects in hypertension model rats.

Free Research Field

医学・薬学・薬理系薬学・神経科学