• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Regulatory mechanism of P2X7 receptor by its splice variants, and relationship of its altered functional expression to psychiatric diseases

Research Project

  • PDF
Project/Area Number 24590128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

NAGASAWA Kazuki  京都薬科大学, 薬学部, 教授 (30228001)

Co-Investigator(Kenkyū-buntansha) NISHIDA Kentaro  京都薬科大学, 薬学部, 助教 (20533805)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsATP / 脳・神経 / 受容体
Outline of Final Research Achievements

The activity of P2X7 receptors expressed in cultured astrocytes of SJL-strain mice, which exhibit extremely aggression characteristics, was greater than the case of ddY-strain mice, and this was due to the less expression levels of P2X7 receptor splice variant 2 and 3 in the formers. In addition, we demonstrated that spontaneous activation of P2X7Rs expressed by astrocytes plays a role in regulation of engulfing activity of astrocytes. Finally, we found that in activated astrocytes, which was induced by stress-load such as oxidative stress, expression of P2X7 receptors at the plasma membrane was decreased by increased expression of its splice variant 2 and 3, resulting in decreased engulfing activity. These findings indicated that P2X7 receptor is regulated by expression levels of its splice variants, and its activity plays a role in regulation of astrocytic functionality.

Free Research Field

神経科学

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi