2014 Fiscal Year Final Research Report
Abnormal LPA receptor signaling in cancer
| Project/Area Number |
24590129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJIUCHI Toshifumi 近畿大学, 理工学部, 教授 (10254492)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リゾホスファチジン酸 / がん / 変異体 / 脂肪酸 |
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| Outline of Final Research Achievements |
Lysophosphatidic acid (LPA) is a lysolipid mediator that exerts various physiological actions. The effects of LPA are mediated through at least six types of LPA receptors, including LPA1~LPA6. Involvement of LPA receptor-mediated signaling in cancer growth has been so far suggested. The present study demonstrated that LPA receptor mutants observed in cancer tissues showed abnormal cellular distribution and intracellular signaling. Further analysis for LPA signaling in a certain type of ovarian cancer cell line revealed that the effects of LPA signaling were partly attributed to a fatty acid liberated from LPA.
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| Free Research Field |
細胞生物学
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