Functional analysis of regulatory roles of chondroitin sulfate chains in neurite outgrowth for neuro-regenerative therapies

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: MIKAMI TADAHISA 神戸薬科大学, 薬学部, 講師 (20330425)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: コンドロイチン硫酸 / 受容体 / 神経突起伸長 / 細胞外シグナル分子 / シグナル伝達 / 発現制御

Outline of Final Research Achievements

Chondroitin sulfate (CS) is a multifunctional molecule that is widely distributed in extracellular spaces. In central nervous system, the pathological features of CS as major axon growth inhibitory molecules have attracted much attention, whereas several CS preparations have profound stimulatory effects on neurite outgrowth. Recently, our group demonstrated the existence of CS receptor molecules for the first time, and established a new concept that CS can act as a dynamic extracellular signaling molecule that trigger intracellular signaling cascades. Therefore, this project was to investigate the molecular mechanisms for the CS-mediated regulation in neurite outgrowth for neuro-regenerative therapies.

Free Research Field

生化学・分子生物学・糖鎖生物学