2014 Fiscal Year Final Research Report
Nnew approch to discover the medicinal seeds using the cross-reactivity of monoclonal antibody
| Project/Area Number |
24590139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | monoclonal antimody / cross-reactivity / ELISA / morphine / polyacetylene / papuamine / haliclonadiamine |
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| Outline of Final Research Achievements |
Cross-reactivity is the reaction against a different but similar antigen. We hypotheses that the recognition site of antibody is equivalent to the receptor domain, and utilizing the cross-reactivity, it makes possible to discover the new structures which possess the equivalent of pharmacophar as a small molecule antigen. We developed the new approach for natural product drug discovery utilizing the cross-reactivity of anti-morphine monoclonal antibody (MAb).
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| Free Research Field |
天然物化学
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