2014 Fiscal Year Final Research Report
Synthesis and evaluation of antiviral activities of branched oxetanosine A.
| Project/Area Number |
24590144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nihon Pharmaceutical University (2013-2014)
Showa University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | オキセタノシン / グリカール / オキセタン / 求電子付加 / グリコシル化 / ラジカル反応 / 抗ウイルス活性 |
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| Outline of Final Research Achievements |
When oxetanoid glycal was reacted silylated N6-benzoyladenine in the presence of N-iodosuccinimide, the desired glycoside was obtained in 25% yield. Reaction of the glycoside with allyltributylstannanen was carried out in the presence of AIBN to furnish 3'-C-allyl derivative in 78% yield as diastereomeric mixture. The allylated nucleoside wa sublected hydride reduction of the ester moety followed by NaOMe-mediated removal of the benzoyl group of the adenine moiety provied the target 3'-C-allyl-oxetanosine A.
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| Free Research Field |
医薬品化学
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