2014 Fiscal Year Final Research Report
Development of antibodies with Abeta hydrolyzing activity for treatment of Alzheimer's disease
| Project/Area Number |
24590151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 医薬品化学 |
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| Outline of Final Research Achievements |
Accumulation of amyloid-β-peptide (Aβ) in the brain is one of the pathological hallmarks of Alzheimer’s disease (AD) and has been considered to play a crucial role in the neurodegenerative events underlying AD. Catalytic Abs capable of binding and hydrolyzing Aβ are candidates as immunotherapeutic agents for AD due to their ability to inactivate multiple Aβ molecules per Ab molecule.
In this study, we designed and synthesized phosphonate esters that could be induced production of Abs capable of hydrolytic activity. Evaluation of phosphonate esters containing a hydroxyl group or motif that can capture a water molecule was carried out using trypsin as a model of catalytic Abs. According to the assay results, most promising phosophonate ester to induce catalytic Abs was used for the synthesis of the reagent that can induce Abs capable of binding and hydrolyzing Aβ.
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| Free Research Field |
医薬品化学
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