2014 Fiscal Year Final Research Report
Therapeutics for renal failure by regulation of uremic toxin excretion
| Project/Area Number |
24590177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 尿毒素 / 慢性腎臓病 / 急性腎傷害 / ミトコンドリア / トランスポーター / エリスロポイエチン / シスプラチン / 虚血再灌流 |
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| Outline of Final Research Achievements |
In patients with chronic kidney disease(CKD) and acute kidney injury(AKI), the uremic toxins might promote renal damages and anemia by cytotoxicities and repression of the expression of renal uremic toxin transporter SLCO4C1and hematopoietic hormone erythropoietin (Epo) produce in the klidney. We explored the new drugs for kidney disease by screening compounds library with Epo producing cells and kidney derived cells. We identified newly synthesized indole compounds and those compounds improved the renal functions and the kidney pathological scores in two mice AKI models, ischemic repercussion injury-model and cisplatin nephropathy. The indole compounds increased the intra cellular ATP content in kidney derived culture cells. The indole derivatives could be the new therapeutic agents for kidney diseases.
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| Free Research Field |
腎臓内科
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