Expression and functional characterization of cancer-type organic anion transporting polypeptide 1B3 in human lung and colon cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Chiba University
• Principal Investigator: FURIHATA Tomomi 千葉大学, 薬学研究科(研究院), 助教 (80401008)
• Co-Investigator(Kenkyū-buntansha): MOTOHASHI Shinichiro 千葉大学, 大学院医学研究院, 教授 (60345022)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: がん分子標的 / がんバイオマーカー / トランスポーター

Outline of Final Research Achievements

We recently identified cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in human several cancer tissues. Since Ct-OATP1B3 mRNA expression characteristics in colon and lung cancer and its clinical significance have yet to be identified, in this study, we sought to identify clinical significance of Ct-OATP1B3 mRNA expression in lung and colon cancer by characterizing its expression profile in two groups of matched-colon tissue pairs (cancer/normal). Our results showed that Ct-OATP1B3 mRNA expression levels was significantly higher in cancer tissues than in normal tissues in colon cancer. Similar results were also obtained from lung cancer tissues. Therefore, we concluded that Ct-OATP1B3 mRNA expression is primarily associated with cancer tissues in colon and lung cancer, and that Ct-OATP1B3 mRNA may become a promising biomarker for colon cancer detection.

Free Research Field

薬物動態