Analysis of the drug-induced lung toxicity in relation to transdifferentiation of type II cells into type I cells and epithelial-mesenchymal transition

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: YUMOTO Ryoko 広島大学, 医歯薬保健学研究院(薬), 講師 (70379915)
• Co-Investigator(Renkei-kenkyūsha): TAKANO Mikihisa 広島大学, 大学院医歯薬保健学研究院, 教授 (20211336)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬学 / 薬剤性肺障害 / 肺胞上皮細胞 / II型ーI型分化転換 / 上皮間葉転換 / TGF-β1

Outline of Final Research Achievements

Transforming growth factor-β1 (TGF-β1) induced epithelial-mesenchymal transition (EMT) in cultured alveolar epithelial cell lines, RLE-6TN cells and A549 cells. Anticancer drugs such as bleomycin and methotrexate also induced EMT-like phenotypical changes in these cell lines. In addition, the involvement of TGF-β1 pathway in the EMT induced by these drugs was suggested. These findings would be helpful for the development of a novel strategy to predict the lung toxicity of drug candidates.

Free Research Field

薬剤学