Physiological role of a novel nucleobase transporter in the utilization of extracellular purine nucleobases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590202
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Tokyo University of Pharmacy and Life Science (2013-2014); Nagoya City University (2012)
• Principal Investigator: INOUE Katsuhisa 東京薬科大学, 薬学部, 教授 (50315892)
• Co-Investigator(Kenkyū-buntansha): YUASA Hiroaki 名古屋市立大学, 大学院薬学研究科, 教授 (20191471) ; OHTA Kinya 名古屋市立大学, 大学院薬学研究科, 助教 (90448704)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 核酸塩基 / トランスポーター / 促進拡散 / 代謝酵素

Outline of Final Research Achievements

The purine salvage pathway plays a major role in the production of nucleotides, relying heavily on the supply of nucleobases and nucleosides from extracellular sources. Although specific transporters have been suggested to be involved in facilitating their transport across the plasma membrane in mammals, those which are responsible for utilization of extracellular nucleobases remain unknown. In this research project、we identified ENBT1 as a facilitative and purine-selective nucleobase transporter that mediates, in cooperation with salvage enzymes, the cellular uptake of extracellular purine nucleobases, a key step in the efficient utilization of nucleobases.

Free Research Field

医療系薬学