2014 Fiscal Year Final Research Report
Molecular mechanism of the tissue-specific expression of the hydrolases which enzymes related to structure activity relationship of pro-drugs
| Project/Area Number |
24590206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | カルボキシルエステラーゼ / プロドラッグ / 代謝活性化 / AADAC |
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| Outline of Final Research Achievements |
Human carboxylesterase (CES), butyrylcholinesterase (BuChE), arylacetamido deacetylase (AADAC), cholesteroesterase(ChlE) and paraoxonase (PON) efficiently catalyze the hydrolysis of a variety of ester- and amide-containing chemicals as well as drug to the respective free acid. These hydrolases catalyze the hydrolysis of the different structure of clinically used pro-drugs. In this study, we investigated the tissue specific expression and the structure activity relationship of pro-drugs of these hydrolase enzymes.
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| Free Research Field |
薬物代謝学
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