2014 Fiscal Year Final Research Report
Gender as a susceptibility factor for drug-induced liver injury
| Project/Area Number |
24590207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 薬剤性肝障害 / 性差 / アセトアミノフェン / 四塩化炭素 / グルタチオン / サイトカイン / エストロゲン / 脂質過酸化 |
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| Outline of Final Research Achievements |
Gender differences in drug-induced liver injury (DILI) were investigated in mice. Male mice were mostly susceptible to DILI, and following common and distinctive features in different models were suggested as susceptibility factors. Rapid recovery of hepatic GSH and the resultant resistance to DILI in females were found in acetaminophen hepatotoxicity. On the other hand, severe lipid peroxidation in males and high expression of IL-6 in females were found in carbon tetrachloride hepatotoxicity along with resistance to DILI in females. These factors with gender differences also can be indicative of determinants for interindividual difference of DILI.
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| Free Research Field |
医療薬学
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