2014 Fiscal Year Final Research Report
The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in the Central Nervous System
| Project/Area Number |
24590213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DEGUCHI Yoshiharu 帝京大学, 薬学部, 教授 (40254255)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血液脳関門 / トランスポーター / 有機カチオン |
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| Outline of Final Research Achievements |
The human blood-brain barrier cells have been shown to retain the proton-coupled organic cation antiporter, which is involved in efficient blood-to-brain transport of oxycodone. Further, tramadol, a weak opioid, was also actively transported into the brain across the blood-brain barrier by the proton-coupled organic cation antiporter. Both apomorphine enantiomers were efficiently transported into the brain with similar kinetic parameters. The proton-coupled organic cation antiporter is mediated efficient brain transport of apomorphine and it should be relevant to the rapid onset of pharmacological action of this rescue drug.
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| Free Research Field |
薬物動態学
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