Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methyl prednisolone and essential unsaturated fatty acids

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Tohoku Pharmaceutical University (2014); Tokyo University of Pharmacy and Life Science (2012)
• Principal Investigator: TOMITA MIKIO 東北薬科大学, 薬学部, 教授 (60207610)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 炎症性腸疾患 / Methylprednisolone / P-glycoprotein / 薬物療法 / 栄養療法 / 必須不飽和脂肪酸 / Dextran sodium sulfate

Outline of Final Research Achievements

Linoleic acid (LA) and α-linolenic acid (α-LnA) decrease the absorption of methylprednisolone (MP) from small intestine in inflammatory bowel disease (IBD) model rats and have delivery effects to large intestine to MP. LA and α-LnA have anti-inflammatory effects and regulatory effects on expression and function of P-glycoprotein (P-gp) in small intestine. It suggests that administration of these essential unsaturated fatty acids not only prevent progress of IBD and but also normalize intestinal absorption and disposition of the drug which is a substrate of P-gp in vivo. More experimental information and data are necessary for more efficient administration schedule of drugs in IBD therapy.

Free Research Field

医歯薬学