2014 Fiscal Year Final Research Report
Safety Assessment and Pharmacokinetic Analysis of a Novel Organ-targeting-Water-Soluble-Carbon Nanotube Toward DDS Application
| Project/Area Number |
24590220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Miki 名城大学, 薬学部, 准教授 (70345594)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Yoshinori 名城大学, 理工学部, 教授 (30076591)
HARUNA Mitsumasa 名城大学, 薬学部, 教授 (10076755)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | カーボンナノチューブ / ドラッグデリバリー / 水溶化 / 蛍光ラベル化 / 体内動態特性 / 異物代謝能 / 薬物代謝酵素 |
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| Outline of Final Research Achievements |
Recently, clinical application of carbon nanotube (CNTs) has been proposed as drug delivery agents. Polyethylene glycol and fluorescent dye, Cy5, was bound to CNTs to synthesize Cy5-PEG-CNT towards application of CNTs as DDS carrier. After intravenous administration, Cy5-PEG-CNT was not metabolized, nor degraded in rat body, and was excreted immediately into urine and bile. In order to obtain Cy5-PEG-CNT with uniform physicochemical properties, classification of length with membrane filter, or application of CNTs synthesized by enhanced Direct Injective Pyrolytic Synthesis method were attempted, but Cy5-PEG-CNT with sufficient amount of Cy5 was not obtained. On the other hand, exposure of CNTs down-regulated several types of CYP molecular species in rat and human liver derived cells.
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| Free Research Field |
医歯薬学
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