2014 Fiscal Year Final Research Report
Development of hybrid taste sensor system combined culture of taste bud with voltage sensitive dye
| Project/Area Number |
24590226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Miyako 武庫川女子大学, 薬学部, 講師 (20369028)
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| Co-Investigator(Renkei-kenkyūsha) |
HAZEKAWA Mai 武庫川女子大学, 薬学部, 助教 (10509186)
HARAGUCHI Tamami 武庫川女子大学, 薬学部, 助教 (10550741)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 味蕾細胞 / キニーネ / マクロライド / パターン分析 |
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| Outline of Final Research Achievements |
Cultured taste cell system was developed to evaluate membrane potential -time profile caused by treatment of typical bitterness substance, quinine as an alkaloid, macrolides, and Fluvoxamine. The membrane potential time profiles were monitored for above model substances and its profile was classified. The pattern seemed to be clarified by molecular weight, acidity, and lipophilicity for the targeted substance. The duration of membrane potential suggest after -bitterness of the drug.
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| Free Research Field |
医療系薬学
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