2015 Fiscal Year Final Research Report
Analysis of gradual steps for a specificity formation of cranial placode by using a novel neural plate explant culture.
| Project/Area Number |
24590244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 神経板 / 神経板外縁 / 神経堤 / 前プラコード外胚葉 / プラコード / BMP4 / FGF2 |
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| Outline of Final Research Achievements |
A new 'two-step model' has been advocated for the induction of the cranial placode along with the neural crest formation. According to the model, our explanation on the result of the neural plate explant culture should be corrected in part: FGF2 signal possibly has an antagonistic effect on BMP4 signal in our culture system; the induced squamous epithelium has characteristics of an immature composite of the neural border/pre-placodal ectoderm/non-neural ectoderm.
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| Free Research Field |
神経発生学、組織学、進化発生学
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