2014 Fiscal Year Final Research Report
in vivo imaging of transcytosis of lysosomal enzymes
| Project/Area Number |
24590249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kagoshima University (2014)
Niigata University (2012-2013) |
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Principal Investigator |
SHIBATA Masahiro 鹿児島大学, 医歯(薬)学総合研究科, 教授 (10343253)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リソソーム / カテプシン |
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| Outline of Final Research Achievements |
Lysosomal Storage Diseases (LSDs) are a group of congenital metabolic disorders caused by lysosomal dysfunction. Enzyme replacement therapy which has been adopted to several LSDs has no effect on neurons due to the existence of blood-brain barrier. To elucidate the mechanism of the transcytosis of lysosomal enzymes in nervous system, we developed a chick model to monitor lysosomal enzymes in vivo using a two-photon laser scanning microscopy.
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| Free Research Field |
解剖学
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