Study of the molecular mechanisms of brain sex differentiation of the SF-1 KO mouse

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590257
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Aichi Gakuin University
• Principal Investigator: IKEDA YAYOI 愛知学院大学, 歯学部, 教授 (00202903)
• Co-Investigator(Kenkyū-buntansha): IKEDA Masaaki 東京医科歯科大学, 医歯学総合研究科, 准教授 (20193211)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳の性分化 / 性ホルモン / ノックアウトマウス

Outline of Final Research Achievements

To study the molecular mechanisms of brain sex differentiation, we analyzed the expression of several markers in the SF-1 knockout (KO) mice using immunohistochemistry. The localization and the positive cell number for these markers of SF-1 KO male and female mice were similar to those of WT females, indicating that the two brain regions of SF-1 KO male mice are feminized. The results support the idea that perinatal gonadal hormones are required for masculinization of the brain.

Free Research Field

医歯薬学