An Analysis of dynamic cardiac regulation during active state in mice

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590268
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Akita University
• Principal Investigator: SHINICHI SATO 秋田大学, 医学(系)研究科(研究院), 非常勤講師 (10375305)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 精神的ストレス / ストレス反応 / 情動系 / 自律神経 / 心拍数 / 心房細動 / 睡眠 / 自由行動

Outline of Final Research Achievements

I have developed a flat-plate electrocardiogram/piezoelectric-element hybrid sensor for continuous electrocardiographic recording in freely-moving mice without the need for electrode-implantation surgery and made a patent application on the hybrid-sensor system (#2015-058838). As the sensor required the sweating (emotional sweating) on the soles of mice for the electrocardiographic recording, experiments were performed during under stress and during sleep, and there were several findings as follows: (1) Mice exhibit heartrate elevation with sweating on their soles as psychological-stress response when exposed to sounds or vibration and when being gazed at by an experimenter. (2) In contrast to humans, mice exhibit sweating on their soles during sleep. (3) The response of (1) becomes a more dynamic change in heart rate when conducted during sleep, and furthermore, mice exhibit an arrhythmia thought to be the atrial fibrillation.

Free Research Field

生理学、睡眠科学、電子工学