2014 Fiscal Year Final Research Report
Dynamics of sperm chromatin
| Project/Area Number |
24590269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATA Kyosuke 筑波大学, 学長 (40180492)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ヒストンシャペロン |
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| Outline of Final Research Achievements |
Sperm chromosome forms highly condensed chromatin structure during spermatogenesis to send their information to next generation. We focus on a biological similarity between adenovirus infection cycle and spermatogenesis/fertilization. A histone chaperone, TAF-I, is not only able to remodel adenoviral chromatin structure, but also to make sperm chromatin decondensed in vitro. A series of experiments suggests that TAF-I is involved in cell growth during differentiation and development through its histone chaperone activity.
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| Free Research Field |
分子生物学
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