2014 Fiscal Year Final Research Report
The new activation mechanisms in TRPM2 channel and role of cell death
| Project/Area Number |
24590275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | TRPM2 / TRP / イオンチャネル / 細胞容積調節 / てんかん |
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| Outline of Final Research Achievements |
TRPM2 is activated by oxidative stress and is a key player in immune system. However, there are no report that the accessory protein can regulate the TRPM2 activity. Here, we found two kinds of protein which regulate TRPM2 activity, EFHC1, CD38, in this project. In hypertonic solution, the TRPM2 is regulated by CD38 and, that is involved in volume regulation mechanisms. In the brain, the TRPM2 activity is enhanced by EFHC1, that is related to epilepsy. Together, we successfully found new activation mechanisms for TRPM2 activation.
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| Free Research Field |
細胞生理
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