Effect of preconditioning and postconditioning on ischemic/reperfusion injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KAMADA Kazuhiro 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80616350)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 虚血再灌流障害 / プレコンディショニング / ポストコンディショニング

Outline of Final Research Achievements

I/R injury is reduced by preconditioning with brief periods of vascular occlusion (ischemic preconditioning: IPC) . Ischemia followed by also more short periods of reperfusion immediately after the ischemia and just before the phase of reperfuion that attenuate postischemic injury (ischemic postconditioning: IPoC). The aim of this study was to evaluate the postischemic antiinflammatory effects of ischemic postconditioning in murine small intestine. Male C57BL/6 mice were using in this study. Mucosal injury and inflammation in the small intestine were evaliated biochemically and histologically. I/R induced severe mucosal injury and neutrophil infiltration. Assessed by tissue associated myeloperoxidase activity. In IPoC group, the post I/R injury in animal small intestine was slightly attenuated compared with I/R group.

Free Research Field

生理学　微小循環