Roles of tissue-fibrinolytic system in bone/cartilage regeneration

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590289
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Kinki University
• Principal Investigator: KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
• Co-Investigator(Kenkyū-buntansha): KAWAO Naoyuki 近畿大学, 医学部, 講師 (70388510)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨・軟骨再生 / 骨修復 / 線溶 / 骨形成 / プラスミノゲン / プラスミノゲンアクチベーター / PAI-1 / 血管形成

Outline of Final Research Achievements

Previous evidence suggested that tissue-fibrinolytic system and subsequent proteolytic system and growth factor induction play important roles in tissue repair. We therefore investigated the roles of tissue-fibrinolytic system in bone repair and regeneration in this study. We established the model to evaluate the process of bone repair and regeneration by making a bone defect in mouse femorae. We demonstrated that plasminogen is crucial for bone repair process using plasminogen-deficient mice. Moreover, tissue-type plasminogen activator (tPA) is involved in bone repair using tPA-deficient mice. In that study, we showed that tPA enhances the proliferation of osteoblasts through Annexin 2 and MAP kinase.

Free Research Field

生理学