Involvement of Sirt1 in the circadian proliferation of the neural stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Tohoku University
• Principal Investigator: MORIYA Takahiro 東北大学, 薬学研究科(研究院), 准教授 (80298207)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Masaki 東北工業大学, 工学部, 教授 (90332981)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経幹細胞 / 体内時計 / 時計遺伝子 / Sirt1 / 脱アセチル化酵素

Outline of Final Research Achievements

In the hippacampus, it was reported that the cell division occurs during specific time-window in a day. However, its mechanism remains to be fully clarified. In this study, we tried to clarify how the molecular clock regulates the circadian proliferation of the neural stem cells. We found that Sirt1 is causally involved in the circaidan proliferation of the neural stem cells using automatic real-time monitoring system for cell division.

Free Research Field

神経薬理学