2014 Fiscal Year Final Research Report
Total research for the sarcopenia from rats to human using multiple level analysis, such as motor unit in vivo, cell, molecule and nucleic acid.
| Project/Area Number |
24590303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIYAMA Yoshiyasu 東海大学, 医学部, 准教授 (80317784)
HOSHI Akio 東海大学, 医学部, 准教授 (90453711)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 運動単位 / アミノ酸代謝 / サイミジン代謝 / Ib抑制 / 筋張力測定 / 放射性同位元素 / 骨格筋内幹細胞 / dynapenia |
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| Outline of Final Research Achievements |
The physiological mechanisms of the age-related loss of muscle mass (sarcopenia) was investigated for preventive purposes. The results suggested that the symptoms such as alteration of motor units, slower muscle contraction velocity and the functional reduction of sarcoplasmic reticulum, already began in middle aged that showed no other signs of sarcopenia. Thus, prevention should be started in middle age that could be retained relatively higher movement ability. In addition, in vivo cellular environment, such as the cachexia with reduced physical activities, may be a major cause for sarcopenia and/or dynapenia with a functional depression of muscle-derived cells. Therefore, stable nutrient intake and maintaining of humoral balance are important for the prevention.
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| Free Research Field |
神経筋生理学、運動生理学
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