2015 Fiscal Year Final Research Report
Elucidation of spatio-temporal regulation of the intracellular configuration of GPCR-signaling complex
| Project/Area Number |
24590311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Sukegawa JUN 東北大学, 医学系研究科, 客員教授 (30187687)
SATO Takeya 東北大学, 医学系研究科, 准教授 (10312696)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 受容体 / チャネル / 輸送系 / シグナル情報伝達系 |
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| Outline of Final Research Achievements |
G-protein coupled receptors are located at the cell surface to transduce the extracellular information into the cells by converting it as a second messenger. Following transducing the signal, GPCR are sequestrated from the cellular surface by interacting with many cytoplasmic proteins. These GPCR-interacting proteins (GIPs) are crucial for the regulation of the intracellular localization and the signaling of GPCR, however, the mechanisms of the regulation between the GIPs and GPCR remained unresolved. We have focused on one of the GPCR, growth hormone releasing hormone receptors and its interacting protein, PICK1. We have found that PICK1 regulated the cell surface expression and the intracellular signaling of GHRHR. Furthermore, the interaction of PICK1 with GHRHR could regulate the cellular proliferation of human prostate adenocarcinoma cells, LNCap.
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| Free Research Field |
薬理学
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