2014 Fiscal Year Final Research Report
Research and application of allosteric ligands directed to G-protein coupled receptor heteromers
| Project/Area Number |
24590327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 薬物受容体 / ヘテロマー複合体 |
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| Outline of Final Research Achievements |
Members of G-protein coupled receptor family proteins have been drug targets of more than 30% of medicines currently used in clinics. It has been turned out that G-protein coupled receptors (GPCRs) exist as dimers or oligomers, in which homomeric as well as heteromeric receptor complex can be formed. There is no method to control GPCR heteromer function allosterically. We searched for new heteromer opioid receptor by developing new evaluation method. Our data indicated that opioid efficacy and side effects could be modulated though heteromer receptors.
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| Free Research Field |
薬理学
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