2014 Fiscal Year Final Research Report
Mechanisms for the intracellular calcium dependent automaticity in the pulmonary-vein myocardium
| Project/Area Number |
24590334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肺静脈心筋 / 活動電位 / 細胞内カルシウム / 心房細動 |
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| Outline of Final Research Achievements |
Intracellular Ca2+-dependent electrical activity was observed in the isolated pulmonary-vein myocardium from small experimental animals, guinea-pig, rat and mouse. The activity was constant in the guinea-pig while intermittent in the rat and mouse. Intracellular Ca2+ released from the sarcoplasmic reticulum through the ryanodine receptor or the IP3 receptor causes a depolarization when pumped out of the cell by the sodium-calcium exchanger, which triggers the firing of the action potential. The electrical activity was induced by alpha- or beta-adrenergic receptor stimulation, and was inhibited by muscarinic receptor stimulation. Thus, it appears possible to control the pulmonary-vein automaticity through pharmacologica modification of intracellular Ca2+ dynamics and autonomic nerve influence.
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| Free Research Field |
薬理学
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