Mechanistic and therapeutic investigation of the outside fibroblasts involving the inner neointima formation after implantation of PTFE grafts.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590336
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka Medical College
• Principal Investigator: JIN DENAN 大阪医科大学, 医学部, 講師 (90319533)
• Co-Investigator(Renkei-kenkyūsha): TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PTFE / 人工血管 / 内腔狭窄 / キマーゼ / キマーゼ阻害薬

Outline of Final Research Achievements

The most common way to provide vascular access for hemodialysis in patients is to either create a native arteriovenous (AV) fistula or to graft an artificial vessel made by polytetrafluoroethylene (PTFE) between a native artery and vein in a clinical setting. However, the creation of a native AV fistula is often restricted due to the lack of suitable vascular sites in patients with end-stage renal disease. Thus, the AV graft currently accounts for the majority of vascular access routes in hemodialysis patients. Unfortunately, in most cases, patency of the AV graft as vascular access route is often less than 2 years. Therefore, not only the economic costs for this type of treatment, but also the need for surgical revision to correct the poor patency rate in hemodialysis patients has become a very big problem.
In this report, we will introduce our attempts for the treatment of vascular access failure in the dog AV graft models by using pharmacological and physical fashions.

Free Research Field

医歯薬学