Molecular mechanism of transcriptional regulation during chronic hypoxic response

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590343
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAKAYAMA Koh 東京医科歯科大学, 難治疾患研究所, 准教授 (10451923)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 低酸素応答 / 転写因子 / がん転移 / 代謝制御

Outline of Final Research Achievements

Hypoxic response plays an important role to maintain homeostasis under hypoxic condition. HIF is a transcription factor which has a central role during hypoxic response. I have identified that the activity of HIF becomes decreased in the chronic phase of hypoxia.
In this study, we tried to identify and characterize the transcription factor(s) which will substitute HIF during the chronic phase. As a result, we identified CREB and NF-κB as such molecules. Further, these factors had a critical role to regulate the tumor metastasis in a mouse transplantation model.

Free Research Field

細胞生物学