2014 Fiscal Year Final Research Report
Analysis of beta-catenin nuclear translocation mechanism through IQGAP1 in Wnt signaling.
| Project/Area Number |
24590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
GOTO Toshiyasu 東京医科歯科大学, 難治疾患研究所, 准教授 (00517518)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | IQGAP1 / Wnt / シグナル伝達 / β-catenin / 核内移行 / アフリカツメガエル |
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| Outline of Final Research Achievements |
Wnt signaling pathway plays an important role in cancer and embryonic development, a key feature of Wnt signaling activation is beta-catenin nuclear translocation.
In this study, we first identified IQGAP1 as a scaffold protein that binds DVL, one of Wnt signaling molecules. Then we analyzed the function of IQGAP1 in Wnt signaling pathway.
As a result, (1) IQGAP1 functioned as a positive regulator of Wnt signaling. (2) IQGAP1 complexed with beta-catenin and DVL2. (3) IQGAP1 was capable to bind with Importin-beta5 and Ran so that the above complex translocated into the nucleus.
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| Free Research Field |
発生生物学
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