2014 Fiscal Year Final Research Report
Elucidation of tumor suppresive role of mammalian Mitotic Exit Network
| Project/Area Number |
24590360
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | Mitotic Exit Network / LATS1 / MYPT1 / PLK1 / APC/C / CDC26 |
|---|
| Outline of Final Research Achievements |
Recent advance of knock out mice study has focused on the importance of Cdk1 on cell cycle progression. However, our understanding of Cdk1 regulation is still limited compared with that of yeast Cdk1. We carried out this project to reveal the significance and signaling mechanism of mammalian MEN (mitotic exit network), one of the Cdk1 regulatory signaling cascade originally found in budding yeast. Although each component of MEN is highly conserved to human, our data strongly suggest signaling of mammalian MEN (e.g. downstream target) is somewhat different from that of the yeast one. Further analysis will be required to elucidate the content of this difference.
|
| Free Research Field |
腫瘍生物学
|
