2014 Fiscal Year Final Research Report
Insuffcient function of ARID1A in tumor.
Project/Area Number |
24590384
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | Gifu University |
Principal Investigator |
TAKEUCHI Tamotsu 岐阜大学, 医学(系)研究科(研究院), 教授 (50226990)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | SWI/SNF / chromatin / ARID1A / TMEM207 / cutaneous adnexal tumor |
Outline of Final Research Achievements |
TMEM207 was first characterized as being an important molecule for the invasion activity of gastric signet-ring cell carcinoma cells and later shown to be associated with insufficient expression of ARID1A, a DNA-binding motif of chromatin remodeling complez, human SWI/SNF. In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, , in which murine TMEM207 was ectopically expressed under a truncated (by 200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene. Notably, a C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors. In addition, we also observed cutaneous adnexal tumors in three other C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines.
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Free Research Field |
人体病理
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