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2014 Fiscal Year Final Research Report

The role of Leukotriene B4 receptor type 2 in skin barrier function.

Research Project

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Project/Area Number 24590386
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionJuntendo University (2014)
Kyushu University (2012-2013)

Principal Investigator

SAEKI KAZUKO  順天堂大学, 医学部, 准教授 (00553273)

Research Collaborator LIU Min  
ISHII Yumiko  
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords脂質 / GPCR / 皮膚
Outline of Final Research Achievements

Leukotriene B4 receptor type 2 (BLT2) is a G protein-coupled receptor (GPCR) highly expressed in epidermal keratinocytes. 12-HHT is a high affinity ligand for BLT2 and produced during blood coagulation in a COX/TxA2S-dependent manner. In this study, we found that 12-HHT/BLT2 axis promotes skin wound healing by accelerating keratinocyte migration. It has been known that aspirin, a COX inhibitor, delays skin wound healing, but the precise mechanisms were wholly unknown. We showed that the impairment of 12-HHT production by aspirin treatment delays wound healing. We also showed that topical application of synthetic BLT2 agonist accelerates skin wound healing in wild-type C57BL/6J mice and diabetic db/db mice. These results suggest the possible application of BLT2 agonist as a therapeutic agent to accelerate wound healing, particularly for intractable wounds, such as diabetic ulcers.

Free Research Field

生化学、免疫学

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Published: 2016-06-03  

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