2014 Fiscal Year Final Research Report
Clinicopathological significance of hypoxia-related molecules in gastrointestinal stromal tumor
| Project/Area Number |
24590413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
ZAITSU Yoko
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 胃腸管間質腫瘍 / 低酸素 / HIF / コハク酸脱水素酵素 / マイクロRNA |
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| Outline of Final Research Achievements |
We examined the significance of accumulation of HIF (hypoxia-induced factor) and SDH (succinate dehydrogenase) in gastrointestinal stromal tumor (GIST). HIF-1α overexpression was correlated with worse prognosis. The expression level of miR-210, a target of HIF-1α was higher in high-grade GISTs. Therefore, HIF-1α accumulation and miR-210 overexpression may play an important role in the progression of GIST. In addition, in a subset of GIST, SDH deficiency may induce the accumulation of HIF-1α.
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| Free Research Field |
人体病理
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