2014 Fiscal Year Final Research Report
Elucidation of the mechanism of Hippo pathway in RCC malignant transformation
| Project/Area Number |
24590415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 泌尿生殖器・内分泌 / 腎癌 / Hippoパスウェイ / SAV1 |
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| Outline of Final Research Achievements |
SAV1, a component of the Hippo pathway, has been reported to be involved in malignant transformation of clear cell renal cell carcinoma (ccRCC). In this study, we found that re-expression of SAV1 inhibited RCC cell proliferation in vitro. In addition, immunohistochemistry frequently demonstrated nuclear localization of YAP1 in ccRCC cases with SAV1. Furthermore, tumors injected with SAV1 stable cell lines showed a decrease of tumor size and growth rate, compared with those of control. Pathway analysis revealed that TGFβ signaling was found to be inhibited in tumors with SAV1 stable cell lines. Based on these data, it is suggested that Hippo pathway including SAV1 acts as tumor suppressor, and downregulation of SAV1 is implicated in malignant formation in ccRCC through TGF beta signaling.
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| Free Research Field |
医歯薬学
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